Beilstein J. Org. Chem.2024,20, 753–766, doi:10.3762/bjoc.20.69
, and the associated undiscovered secondary metabolite biosynthesis genes are called “silent” genes. This review outlines several approaches to further activate the metabolic potential of actinomycetes.
Keywords: actinomycete; co-culture; heat shock metabolites (HSMs); secondary metabolites; silent
identified. These as yet undiscovered secondary metabolite biosynthesis genes are called “silentgenes”, because they are either not expressed or their expression levels are low under normal culture conditions. A number of studies have reported methods to activate these genes, and many new compounds have
important means of activating silentgenes in actinomycetes. Because the cultivation conditions play a key role in metabolite production by actinomycetes, changing these parameters can significantly alter secondary metabolite production patterns. For example, OSMAC (one strain-multi compound), developed by
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Graphical Abstract
Figure 1:
Schematic diagram of methods to activate silent genes in actinomycetes as presented in this review....